Fluorescent chemosensors and imaging agents


主讲人:Tony D James,Professor at the University of Bath




主讲人介绍:Tony D James is a Professor at the University of Bath and Fellow of the Royal Society of Chemistry. He has developed a broad interdisciplinary approach to research, with an underpinning focus on the development of modular sensors, where he has pioneered a range of reporting regimes. His research interests include many aspects of supramolecular chemistry, including molecular recognition, fluorescent sensor design, fluorescence imaging, chiral recognition, saccharide recognition, anion recognition, probes for redox imbalance and theranostic systems. He received his BSc from the University of East Anglia (1986), PhD from the University of Victoria (1991), and was a Postdoctoral Research Fellow in Japan with Seiji Shinkai (1991-95). He was awarded a Royal Society University Research Fellowship at the University of Birmingham (1995-2000) before moving to the University of Bath in 2000. He has been a visiting professor at Tsukuba, Osaka, Kyushu and Sophia Universities, an AMADEus invited professor at the University of Bordeaux and is a guest Professor at East China University of Science and Technology, Xiamen University, Shandong Normal University, Nanjing University, Shaanxi University of Science and Technology, Changzhou University, Zhejiang University, Qufu Normal University, Beijing University of Chemical Technology, Shanghai Normal University, Ewha Womans University, Henan Normal University, Engineering Research Centre for Hainan Bio-Smart Materials and Bio-Smart Devices and is a Hai-Tian (Sea-Sky) Scholar at Dalian University of Technology. He received the Daiwa-Adrian Prize for developing scientific networks with Japan in 2013, the inaugural CASE Prize for establishing scientific networks with China in 2015, the MSMLG Czarnik Award in 2018, Frontiers in Chemistry Diversity Award 2020 and was a Royal Society Wolfson Research Merit Award holder (2017-2022). He has published over 470 publications, including three books, 9 book chapters and 457 papers in international peer reviewed journals. He has an h-index of 88 and is listed by Clarivate as a Highly Cited Researcher in 2022 and 2023.

内容介绍:Sensors and imaging agents can be used to monitor analytes within physiological, environmental, and industrial scenarios. The interactions between the “chemosensor” and an analyte of choice occurs on a molecular level and as such gathering and processing the information is challenging. Therefore, I will outline the trials and challenges encountered in the development of several robust chemical molecular sensors “chemosensors” able to detect such analytes selectively and signal or map their concentration in a biological or environmental scenario. During the talk you will be introduced to a variety of fluorescent probes designed for diols (D-glucose), anions, and redox imbalance. With the goal being the development of chemosensors capable of determining the concentration (and location) of a target species in any medium. Particular attention will be paid to the underlying chemistry associated with the construction of practical chemosensors for both sensing and imaging applications. References 1. X. Luo, B. Tian, Y. Zhai, H. Guo, S. Liu, J. Li, S. Li and T. D. James, Z. Chen. Nat. Rev. Chem., 2023, 7, 800–812. 2. H. Niu, J. Liu, H. M. O’Connor, T. Gunnlaugsson, T. D. James and H. Zhang. Chem. Soc. Rev., 2023, 52, 2322-2357. 3. H.-H. Han, H.-M. Wang, P. Jangili, M. Li, L. Wu, Y. Zang, A. C. Sedgwick, J. Li, X.-P. He, T. D. James and J. S. Kim. Chem. Soc. Rev., 2023, 52, 879-920. 4. J. Yin, L. Huang, L. Wu, J. Li and T. D. James, W. Lin. Chem. Soc. Rev., 2021, 50, 12098-12150. 5. H.-H. Han, H. Tian, Jr., Y. Zang, A. C. Sedgwick, J. Li, J. L. Sessler X.-P. He and T. D. James. Chem. Soc. Rev., 2021, 50, 9391-9429. 6. L. Wu, J. Huang, K. Pu and T. D. James. Nat. Rev. Chem., 2021, 5, 406–421. 7. L. Wu, J. Liu, Ping Li, Bo Tang and T. D. James Chem. Soc. Rev., 2021, 50, 702-734. 8. A. C. Sedgwick, J. T. Brewster II, T. Wu, X. Feng, S. D. Bull, X. Qian, J. L. Sessler, T. D. James, Eric V. Anslyn, and X. Sun. Chem. Soc. Rev. 2021, 50, 9-38.